DSIP (Delta sleep-inducing peptide) is a well-known neuromodulator and natural sleep-promoting nonapeptide with many other physiologic functions. It is typically found in the brain and easily passes the blood-brain barrier. It has been discovered and heavily studied for over 40 years.
It has been used for the treatment of poor sleep, pain conditions, stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti-cancer protein. It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to a variety of stresses. It has also been shown in research to improve hormone levels and physical performance.
Here's an overview of potential DSIP benefits:
DSIP has been described as a sleep-promoting substance rather than a sedative. There is a modulating effect on sleep and wake functions with greater activity in circumstances where sleep is disturbed.
There are essentially 5 stages of sleep, these can be broken down into 2 categories: REM and NREM sleep. Many sleep aids change the time or duration of these sleep cycles. The problem with this is these cycles are ALL associated with important physiological processes and anabolic hormone production. DSIP does not change sleep stages. It increases the ability to go to sleep and offers a more restful sleep.
Delta-sleep-inducing peptide is a neuropeptide that affects a number of endocrine and physiological processes within the central nervous system. DSIP is of primary interest for its abilities to reduce oxidative stress, normalize myocardial contractility. It is also being studied as a potential target in the treatment of major depressive disorder.
DSIP is involved in neuroendocrine regulation and release of anterior pituitary hormones. In humans, DSIP influences the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of circadian rhythms.
Administration of DSIP seems to improve the hormone production/regulation in these glands. For example, it increases LH and growth hormone production while decreasing somatostatin. This results in increased production of desirable hormones (LH, GH), and decreased the production of undesirable ones (cortisol and somatostatin).